Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study. (September 2018)

• Record Type: Journal Article
• Authors: Lete, Iñaki; Mendoza, Nicolás; de la Viuda, Esther; Carmona, Francisco
• Is Part Of: European journal of obstetrics, gynecology, and reproductive biology. Volume 228(2018)
• Page Start: 221
• Page End: 224
• Publication Date: 2018-09
• Subjects: Endometriosis-associated pelvic pain -- Antioxidants -- N-Acetyl cysteine -- Alpha lipoic acid -- Bromelain; Obstetrics -- Periodicals; Gynecology -- Periodicals; Reproductive health -- Periodicals; Gynecology -- Periodicals; Obstetrics -- Periodicals; Reproduction -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; Reproduction -- Périodiques; Verloskunde; Gynaecologie; Voortplanting (biologie); Gynecology; Obstetrics; Reproduction; Electronic journals; Periodicals; Electronic journals; 618.05
• DOI: 10.1016/j.ejogrb.2018.07.002
• Languages: English
• ISSNs: 0301-2115

Abstract

Abstract: Objective: To assess the impact of an antioxidant preparation with N -acetyl cysteine, alpha lipoic acid and bromelain on endometriosis-associated pelvic pain. Study design: Multicenter, open-label, non-comparative clinical trial in a representative sample of women with endometriosis-associated pelvic pain. Results: In total, 398 patients with a mean age of 34.6 ± 7.2 years were treated with a combination of N -acetyl cysteine, alpha lipoic acid and bromelain for 6 months. At baseline, 92.7% of the patients had pain intensity > 4 on the visual analogue scale (VAS); at 3 months of treatment, this percentage decreased to 87.2% (p = 0.074) and at 6 months the percentage was 82.7% (p < 0.05). Conclusions: Women with endometriosis who wish to become pregnant and are treated with a preparation containing N -acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics.