Upregulation of circulating components of the alternative renin-angiotensin system in inflammatory bowel disease: A pilot study. (September 2015)

• Record Type: Journal Article
• Authors: Garg, Mayur; Burrell, Louise M; Velkoska, Elena; Griggs, Karen; Angus, Peter W; Gibson, Peter R; Lubel, John S
• Is Part Of: Journal of the renin-angiotensin-aldosterone system. Volume 16:Number 3(2015:Sep.)
• Page Start: 559
• Page End: 569
• Publication Date: 2015-09
• Subjects: Renin-angiotensin system -- inflammatory bowel disease -- Crohn's disease -- ulcerative colitis -- angiotensin II -- angiotensin (1–7) -- angiotensin-converting enzyme -- angiotensin-converting enzyme 2; Renin-angiotensin system -- Periodicals; 616.132
• DOI: 10.1177/1470320314521086
• Languages: English
• ISSNs: 1470-3203

Abstract

Introduction: The relationship between intestinal inflammation and circulating components of the renin-angiotensin system (RAS) is poorly understood. Materials and methods: Demographic and clinical data were obtained from healthy controls and patients with inflammatory bowel disease (IBD). Plasma concentrations of the classical RAS components (angiotensin-converting enzyme (ACE) and angiotensin II (Ang II)) and alternative RAS components (ACE2 and angiotensin (1-7) (Ang (1-7))) were analysed by radioimmuno- and enzymatic assays. Systemic inflammation was assessed using serum C-reactive protein (CRP), white cell count, platelet count and albumin, and intestinal inflammation by faecal calprotectin. Results: Nineteen healthy controls (11 female; mean age 38 years, range 23–68), 19 patients with Crohn's disease (11 female; aged 45 years, range 23–76) and 15 patients with ulcerative colitis (6 female; aged 42 years, 26–64) were studied. Circulating classical RAS component levels were similar across the three groups, whereas ACE2 activity and Ang (1-7) concentrations were higher in patients with IBD compared to controls (ACE2: 21.5 vs 13.3 pmol/ml/min, p <0.05; Ang (1-7): 22.8 vs 14.1 pg/ml, p <0.001). Ang (1-7) correlated weakly with platelet and white cell counts, but not calprotectin or CRP, in patients with IBD. Conclusions: Circulating components of the alternative RAS are increased in patients with IBD.