Bone breaking infections – A focus on bacterial and mosquito-borne viral infections. (September 2018)

• Record Type: Journal Article
• Authors: Cui, Yan Chao; Wu, Qiong; Teh, Seoh Wei; Peli, Amira; Bu, Gang; Qiu, Yu Sheng; Benelli, Giovanni; Kumar, S. Suresh
• Is Part Of: Microbial pathogenesis. Volume 122(2018)
• Page Start: 130
• Page End: 136
• Publication Date: 2018-09
• Subjects: Arbovirus -- Dengue -- Chikungunya virus -- Mosquito control -- Ross river virus -- Vector competence -- Tuberculosis -- Zika virus; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2018.06.021
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: The recent global resurgence of arthritogenic alphaviruses, including Ross River, chikungunya, and dengue, highlights an urgency for the development of therapeutic strategies. Currently, dengue represents the most rapidly transmitting mosquito-borne viral disease worldwide. By contracting bone breaking diseases, patients experience devastating clinical manifestations involving muscle pain and bone loss. The bone self-repair and regeneration mechanisms can be damaged by the presence of viruses and bacteria. The rapid establishment of dengue epidemic and the severity of bacterial and viral infections affecting the bone stress the urgent need of developing effective interventions. Herein, we review current knowledge on bone breaking infections, covering both bacterial and mosquito-borne viral ones. The mechanisms exploited by these diseases to significantly affect the bone, including interferences with self-repair and regeneration routes, were discussed. In the final section, challenges for future research aimed to treat and prevent bacterial and mosquito-borne bone-breaking infections have been outlined.