Phytochemical investigation of Crepis incana Sm. (Asteraceae) endemic to southern Greece. (October 2018)

• Record Type: Journal Article
• Authors: Barda, Christina; Ciric, Ana; Soković, Marina; Tsoukalas, Michael; Skaltsa, Helen
• Is Part Of: Biochemical systematics and ecology. Volume 80(2018)
• Page Start: 59
• Page End: 62
• Publication Date: 2018-10
• Subjects: Crepis incana -- Chichorieae -- Sesquiterene lactones -- Antibacterial -- Antifungal -- NMR; Chemotaxonomy -- Periodicals; Biochemical variation -- Periodicals; Ecology -- Periodicals; Biochemistry -- Periodicals; Ecology -- Periodicals; Chimiotaxinomie -- Périodiques; Variation biochimique -- Périodiques; Écologie -- Périodiques; 578.012
• DOI: 10.1016/j.bse.2018.06.009
• Languages: English
• ISSNs: 0305-1978

Abstract

Abstract: The genus Crepis L. belongs to the Cichorieae tribe of the Asteraceae family. C. incana Sm. is a narrow endemic species of southern Greece. Crepis L. is well known for its abundance in sesquiterpene lactones. In total, from its aerial parts nine compounds were isolated for the first time, i.e. three guaianolides, grosheimin, crepiside E, crepiside D; two germacranolides, taraxinic acid and its 1′- O -β-d -glucopyranosyl ester, the nor-isoprenoid (3 S, 5R)-loliolide and three flavonoids, luteolin, luteolin 7- O -β-d -glucopyranoside and quercetin 3- O -β-d -glucopyranoside. Furthermore, the root extract afforded two triterpenes, oleanolic acid and lupeol. The structures of the isolated compounds were elucidated by high-field NMR spectroscopy. Graphical abstract: Highlights: First phytochemical investigation of Crepis incana Sm (Asteraceae). Eleven secondary metabolites were isolated, mainly sesquiterpene lactones. The study revealed that the main secondary metabolites were compounds: grosheimin and taraxinic acid and its 1′- O -β-D-glucopyranosyl ester.