Carriers for the targeted delivery of aerosolized macromolecules for pulmonary pathologies. (3rd August 2018)

• Record Type: Journal Article
• Authors: Osman, Nashwa; Kaneko, Kan; Carini, Valeria; Saleem, Imran
• Is Part Of: Expert opinion on drug delivery. Volume 15:Number 8(2018)
• Page Start: 821
• Page End: 834
• Publication Date: 2018-08-03
• Subjects: Aerosol devices -- inhaled macromolecules -- lung delivery -- microcarrier -- nanocarrier -- nanomedicine -- lipid-based systems -- passive and active targeting -- pulmonary pathologies; Drug delivery devices -- Periodicals; Drug delivery systems -- Periodicals; 615.605
• DOI: 10.1080/17425247.2018.1502267
• Languages: English
• ISSNs: 1742-5247

Abstract

ABSTRACT: Introduction: Macromolecules with unique effects and potency are increasingly being considered for application in lung pathologies. Numerous delivery strategies for these macromolecules through the lung have been investigated to improve the targeting and overall efficacy. Areas covered : Targeting approaches from delivery devices, formulation strategies and specific targets are discussed. Expert opinion : Although macromolecules are a heterogeneous group of molecules, a number of strategies have been investigated at the macro, micro, and nanoscopic scale for the delivery of macromolecules to specific sites and cells of lung tissues. Targeted approaches are already in use at the macroscopic scale through inhalation devices and formulations, but targeting strategies at the micro and nanoscopic scale are still in the laboratory stage. The combination of controlling lung deposition and targeting after deposition, through a combination of targeting strategies could be the future direction for the treatment of lung pathologies through the pulmonary route.