Chordoid Gliomas of the Third Ventricle Share TTF-1 Expression With Organum Vasculosum of the Lamina Terminalis. (July 2015)

• Record Type: Journal Article
• Authors: Bielle, Franck; Villa, Chiara; Giry, Marine; Bergemer-Fouquet, Anne-Marie; Polivka, Marc; Vasiljevic, Alexandre; Aubriot-Lorton, Marie-Hélène; Bernier, Michèle; Lechapt-Zalcman, Emmanuèle; Viennet, Gabriel; Sazdovitch, Véronique; Duyckaerts, Charles; Sanson, Marc; Figarella-Branger, Dominique; Mokhtari, Karima
• Is Part Of: American journal of surgical pathology. Volume 39:Number 7(2015)
• Publication Date: 2015-07
• Subjects: TTF-1 -- chordoid glioma of the third ventricle -- lamina terminalis -- circumventricular organs -- RENOP; Pathology, Surgical -- Periodicals; 617.0705
• DOI: 10.1097/PAS.0000000000000421
• Languages: English
• ISSNs: 0147-5185

Abstract

Abstract : Chordoid glioma of the third ventricle (CG3V) is a rare tumor developing in a stereotyped localization. It has been related to the circumventricular organ of the lamina terminalis, in the anterior part of the third ventricle, but its oncogenesis is poorly understood. TTF-1 transcription factor is involved in the development and adult physiology of the ventral forebrain. We studied the histopathologic and immunohistochemical features of a multicentric series of 17 cases of CG3V. We described additional histologic patterns (solid, fibrosing, and fusiform) to the typical chordoid pattern. TTF-1 was constantly expressed in CG3V, as in developing and adult lamina terminalis. The anti-TTF-1 SPT24 clone was more sensitive than the 8G7G3/1 clone. No mutation of IDH1 R132, IDH2 R172, or BRAF V600 codons was found. We showed TTF-1 as a useful marker for the diagnosis of CG3V and the understanding of its oncogenesis.