Serum magnesium level in the first trimester of pregnancy as a predictor of pre-eclampsia – a pilot study. (3rd July 2018)

• Record Type: Journal Article
• Authors: Čabarkapa, Velibor; Bogavac, Mirjana; Jakovljević, Ana; Pezo, Lato; Nikolić, Aleksandra; Belopavlović, Zoran; Mirjana, Djerić
• Is Part Of: Hypertension in pregnancy. Volume 37:Number 3(2018)
• Page Start: 144
• Page End: 153
• Publication Date: 2018-07-03
• Subjects: Assesment -- magnesium -- normal pregnancy -- nutrition -- pre-eclampsia; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2018.1494189
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Objectives : The aim of this study was to evaluate the importance of serum concentration of magnesium (Mg) in the first trimester of pregnancy for predicting pre-eclampsia (PE). Methods : This prospective study included 403 pregnant women over 18, with singleton pregnancy (from 11 to 14 weeks of pregnancy). The subjects were divided into a group who subsequently developed PE (PEKT) ( n = 61), and a group of healthy pregnancies with no complications and with normal outcomes (TNT) ( n = 342). In the first trimester, urea, creatinine, uric acid, Mg, free beta subunit of human chorionic gonadotrophin, plasma protein A related to pregnancy, and C-reactive protein were determined. We followed all subjects until the end of pregnancy. Results : Serum Mg is significantly lower in PEKT than in TNT group ( p < 0.001). The serum first trimester Mg level cutoff at ≤0.81 mmol/L had a sensitivity of 77.0% and specificity of 71.6% for the detection of women with PEKT. The level of serum Mg has the strongest significant positive correlation ( p < 0.05) with the week of gestational outcomes ( R = 0.442), weight ( R = 0.416), and Apgar score ( R = 0.343) of the newborns, and the strongest significant negative correlation with the number of miscarriages ( R = −0.413), serum creatinine ( R = −0.471), and the number of pregnancies ( R = −0.326). The week of gestational outcome is predicted with the greatest reliability by the serum Mg. Conclusions : Serum Mg level during the first trimester of pregnancy is a significant prediction tool for PE and could also play an important role in predicting the week of gestational outcome and birth weight of newborns.