Serum Galectin 7 is Not Useful to Predict Abortion in the First Trimester. (4th May 2018)

• Record Type: Journal Article
• Authors: Cagli, Fulya; Uysal, Gulsum; Oz, Leyla; Akkaya, Hatice; Aksoy, Huseyin; Ulku karakilic, Eda; Acmaz, Gokhan
• Is Part Of: Fetal and pediatric pathology. Volume 37:Number 3(2018)
• Page Start: 141
• Page End: 146
• Publication Date: 2018-05-04
• Subjects: galectin-7 -- pregnancy -- threatened abortion -- prognosis -- lectins; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2018.1453001
• Languages: English
• ISSNs: 1551-3815

Abstract

ABSTRACT: Objective : Galectins are animal lectins that bind to surface glycoproteins expressed at the fetal-maternal interface. The aim of this prospective case–control study was to investigate the possible relationship between levels of maternal serum galectin-7 and threatened abortion (TA) and to determine whether serum galectin-7 had any prognostic value. Methods : This prospective study was conducted between August 2014 and February 2015. Included in the study were 31 consecutive pregnant women who were hospitalized for TA between 6 and 14 weeks of gestation and 33 healthy gestational age matched pregnant women without any symptoms of miscarriage. Serum galectin-7 levels were measured via ELISA. Results : The mean serum galectin-7 levels of the two groups were not significantly different (31 TA patients: 2.84 ± 0.43 pg/mL, 33 controls: 2.785 ± 0.32 pg/mL, p = 0.543). Six pregnancies in the TA group resulted in abortion (19.4%). Conclusion : Serum galectin-7 was not useful for predicting prognosis in TA.