In vitro and in vivo chemo-phototherapy of magnetic TiO2 drug delivery system formed by pH-sensitive coordination bond. (October 2016)

• Record Type: Journal Article
• Authors: Zhang, Huijuan; Ji, Yandan; Chen, Qianqian; Zhu, Xing; Zhang, Xiaoge; Tan, Zhiyuan; Tian, Qianqian; Yang, Xiangbo; Zhang, Zhenzhong
• Is Part Of: Journal of biomaterials applications. Volume 31:Number 4(2016:Oct.)
• Page Start: 568
• Page End: 581
• Publication Date: 2016-10
• Subjects: pH-Sensitive -- phototherapy -- tumor targeting; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328216656098
• Languages: English
• ISSNs: 0885-3282

Abstract

To achieve tumor-specific delivery of doxorubicin, TiO2 @Fe3 O4 /PEI/delivery of doxorubicin conjugates were designed and synthesized. Fe3 O4 could act as magnetically responsive carriers and enhance the visible light photodynamic activities of TiO2 . Delivery of doxorubicin was conjugated via coordination bond. The drug release rate at pH 5.2 was much faster than that at pH 7.4, due to pH-sensitive coordination bond. Besides, TiO2 @Fe3 O4 /PEI/delivery of doxorubicin showed high antitumor efficacy combining with phototherapy, good bio-safety, higher cellular uptake with an external magnetic field, and less toxicity in vitro and in vivo. These results suggested that TiO2 @Fe3 O4 /PEI/delivery of doxorubicin may be promising for high tumor treatment efficacy with minimal side effects in future.