FOXO3 links autophagy to apoptosis. Issue 8 (3rd August 2018)

• Record Type: Journal Article
• Authors: Fitzwalter, Brent E.; Thorburn, Andrew
• Is Part Of: Autophagy. Volume 14:Issue 8(2018)
• Page Start: 1467
• Page End: 1468
• Publication Date: 2018-08-03
• Subjects: Apoptosis -- autophagy -- CRISPR/Cas9 -- FOXO3 -- homeostasis -- MDM2 -- PUMA -- transcription; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2018.1475819
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: The molecular machinery linking macroautophagy (autophagy hereafter) to apoptosis is still being elucidated. A recent study found that the transcription factor FOXO3/FOXO3A (forkhead box O3), which regulates autophagy, is itself regulated by basal autophagy to determine apoptosis sensitivity. Autophagy inhibition confers cell sensitivity to anti-cancer agents, and this effect is explained by the ability of FOXO3 to transactivate the pro-apoptotic gene BBC3/PUMA. Here, we discuss the possibility that FOXO3 acts as a cell surveillance mechanism to correct autophagy perturbations (i.e., autophagy inhibition), and confers apoptosis sensitization if this autophagy imbalance is not rectified.