Terpyridine derivatives as "turn-on" fluorescence chemosensors for the selective and sensitive detection of Zn2+ ions in solution and in live cells. Issue 8 (20th June 2018)

• Record Type: Journal Article
• Authors: Mandal, Tripti; Hossain, Anowar; Dhara, Anamika; Al Masum, Abdulla; Konar, Saugata; Manna, Saikat Kumar; Seth, Saikat Kumar; Pathak, Sudipta; Mukhopadhyay, Subrata
• Is Part Of: Photochemical & photobiological sciences. Volume 17:Issue 8(2018)
• Page Start: 1068
• Page End: 1074
• Publication Date: 2018-06-20
• Subjects: Photochemistry -- Periodicals; Photobiology -- Periodicals; 541.35
• DOI: 10.1039/c8pp00186c
• Languages: English
• ISSNs: 1474-905X

Abstract

Abstract : A terpyridine based compoundL1 was designed and synthesized as an "off–on" chemosensor for the detection of Zn 2+ . Abstract : A terpyridine based compoundL1 was designed and synthesized as an "off–on" chemosensor for the detection of Zn 2+ . ChemosensorL1 showed excellent selectivity and sensitivity toward Zn 2+ by exhibiting a large fluorescence enhancement (∼51-fold) at 370 nm whereas other competitive metal ions did not show any noticeable change in the emission spectra of chemosensorL1 . The chemosensor (L1 ) was shown to detect Zn 2+ ions down to 9.76 μM at pH 7.4. However, chemosensorL1 binds Zn 2+ in a 1 : 2 ratio (receptor : metal) with an association constant of 1.85 × 10 4 ( R 2 = 0.993) and this 1 : 2 stoichiometric fashion is established on the basis of a Job plot and mass spectroscopy. DFT/TD-DFT calculations were carried out to understand the binding nature, coordination features and electronic properties ofL1 and theL1 –2Zn 2+ complex. In addition, this "turn-on" fluorescence probe was effectively used to image intracellular Zn 2+ ions in cultured MDA-MB-468 cells.