Polysaccharide-protein complex-decorated selenium nanosystem as an efficient bone-formation therapeutic. Issue 32 (25th July 2018)

• Record Type: Journal Article
• Authors: Yu, Siming; Luk, Kar-Him; Cheung, Siu-To; Kwok, Kevin Wing-Hin; Wong, Ka-Hing; Chen, Tianfeng
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 32(2018)
• Page Start: 5215
• Page End: 5219
• Publication Date: 2018-07-25
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb01084f
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : PTR-SeNPs with high stability were fabricated, which demonstrated excellent in vitro and in vivo osteogenic effects via BMP-2/Smad-mediated signaling pathways. Abstract : Polysaccharide-protein complex-coated selenium nanoparticles (PTR-SeNPs) system has been rationally designed and identified as a potent bone-formation therapeutic to antagonize osteoporosis. The nanosystem presents high cellular uptake in osteoblast cells and significantly enhances bone formation in vitro and in vivo, mainly through BMP-2/Smad-mediated signalling pathways.