In situ construction of nanonetworks from transformable nanoparticles for anti-angiogenic therapy. Issue 32 (1st August 2018)

• Record Type: Journal Article
• Authors: Li, Bing-Nan; He, Ping-Ping; Yang, Pei-Pei; Zhang, Jing-Ping; Wang, Lei; Wang, Hao
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 32(2018)
• Page Start: 5282
• Page End: 5289
• Publication Date: 2018-08-01
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb00974k
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The defensive networks exhibit transformation-enhanced accumulation and retention (TEAR) effects, and bind and intercept cell-secreted VEGF over particulate and molecular anti-angiogenic agents with high efficiency, leading to anti-angiogenesis. Abstract : Tumor metastasis as the most common reason of death from cancer has always been a great challenge in both clinical and scientific research, where angiogenesis plays a necessary role. Herein, we report an extracellularly transformable nanomaterial for in situ construction of defensive networks on interaction with vascular endothelial growth factor (VEGF) for anti-angiogenic therapy of tumor. The fibrous networks exhibit transformation-enhanced accumulation and retention (TEAR) effects (over 72 h), and bind and intercept cell-secreted VEGF over particulate and molecular anti-angiogenic agents with high efficiency, leading to anti-angiogenesis. This study demonstrates that angiogenesis is positively related to tumor growth as well as tumor metastasis; the anti-angiogenic therapy inhibits tumor metastasis with an inhibition rate of 65.9%. In addition, this extracellular strategy of transformation may be utilized to bind huge amounts of cell-secreted biomolecules/factors or receptors on cell surfaces and inhibit their functionalities for cancer therapy.