A water soluble donor–acceptor–donor conjugated oligomer as a photosensitizer for mitochondria-targeted photodynamic therapy. Issue 66 (31st July 2018)

• Record Type: Journal Article
• Authors: Sun, Jian; Li, Xiao; Du, Ke; Feng, Fude
• Is Part Of: Chemical communications. Volume 54:Issue 66(2018)
• Page Start: 9194
• Page End: 9197
• Publication Date: 2018-07-31
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc05476b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A water soluble donor–acceptor–donor structure with mitochondria-targeting capability exhibits high singlet oxygen generation efficacy for efficient low-energy photodynamic therapy. Abstract : We designed a water soluble benzotriazole-cored donor–acceptor–donor molecule bearing four triphenylphosphonium moieties for mitochondria targeting. The organic molecule showed strong singlet oxygen sensitizing capability ( Φ Δ 0.64), minimal dark cytotoxicity and high photocytotoxicity. The molecule is efficient in photodynamic killing of tumour cells under normal and hypoxia conditions using a very low light flux, and has potential in near-infrared two-photon imaging and photodynamic therapy.