A cytotoxic tantalum(v) half-sandwich complex: a new challenge for metal-based anticancer agents. Issue 68 (10th August 2018)

• Record Type: Journal Article
• Authors: Štarha, Pavel; Trávníček, Zdeněk; Dvořák, Zdeněk
• Is Part Of: Chemical communications. Volume 54:Issue 68(2018)
• Page Start: 9533
• Page End: 9536
• Publication Date: 2018-08-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc05223a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The new and pharmacologically promising electroneutral half-sandwich Ta(v )-dichlorido Schiff-base complex was described. Abstract : Despite the biological relevance of complexes of various transition metals, tantalum complexes have long been neglected by bioinorganic chemists. Herein, we demonstrate potential chemotherapeutic applicability of the [Ta(η 5 -Cp*)Cl2 (salaph)] (1 ) complex, containing deprotonated Schiff base 2-{( E )-[(2-hydroxyphenyl)imino]methyl}phenol (H2 salaph), which shows strong cytotoxicity in cancer cells, related to the induction of apoptosis and apoptosis-related processes, but shows low cytotoxicity in healthy cells.