Pretreatment Neutrophil-Lymphocyte Ratio in Salivary Gland Tumors Is Associated with Malignancy. (December 2016)

• Record Type: Journal Article
• Authors: Damar, Murat; Dinç, Aykut Erdem; Erdem, Duygu; Aydil, Utku; Kizil, Yusuf; Eravcı, Fakih Cihat; Bişkin, Sultan; Şevik Eliçora, Sultan; Işik, Hüseyin
• Is Part Of: Otolaryngology--head and neck surgery. Volume 155:Number 6(2016:Dec.)
• Page Start: 988
• Page End: 996
• Publication Date: 2016-12
• Subjects: salivary gland tumors -- neutrophil-lymphocyte ratio -- inflammatory marker -- high-grade malignant tumor; Head -- Surgery -- Periodicals; Neck -- Surgery -- Periodicals; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0194599816659257
• Languages: English
• ISSNs: 0194-5998

Abstract

Objective: To assess pretreatment levels in the counts and percentages of leukocytes and the neutrophil-lymphocyte ratio (NLR) in benign and malignant salivary gland tumors (SGTs) while investigating whether NLR is an inflammatory marker for distinguishing low- from high-grade parotid gland tumors. Study Design: Case series with chart review. Setting: Tertiary referral center. Subjects and Methods: This study was performed on 182 patients with SGTs (age range: 16-87 years; 93 male and 89 female) who were treated between January 2010 and May 2015. Pretreatment counts and percentages of leukocytes and NLR were measured preoperatively in benign and malignant tumors. Results: Mean neutrophil percentage (63.50% ± 12.11% vs 58.76% ± 8.20%, P = .008) and NLR (3.29 ± 3.13 vs 2.13 ± 1.26, P = .008) were significantly higher in patients with malignant SGTs than in patients with benign SGTs. Mean lymphocyte count (2.42 ± 0.72 10 3 /mm 3 vs 1.97 ± 0.87 10 3 /mm 3, P < .001) and percentage (30.67% ± 7.68% vs 26.86% ± 10.15%, P = .011) were lower in patients with malignant SGTs than in patients with benign SGTs. Mean lymphocyte percentage and NLR were significantly different between low- and high-grade malignant parotid gland tumors ( P = .026 and P = .030, respectively). Conclusion: Elevated NLR could be an inflammatory marker to distinguish low- from high-grade malignant parotid gland tumors.