Bone morphogenetic proteins for articular cartilage regeneration. Issue 9 (September 2018)

• Record Type: Journal Article
• Authors: Deng, Z.H.; Li, Y.S.; Gao, X.; Lei, G.H.; Huard, J.
• Is Part Of: Osteoarthritis and cartilage. Volume 26:Issue 9(2018)
• Page Start: 1153
• Page End: 1161
• Publication Date: 2018-09
• Subjects: Chondrocyte -- Cartilage -- Osteoarthritis -- Bone morphogenetic proteins -- Matrix metalloproteinases; AC articular cartilage -- Ad. adenoviral -- ADSCs adipose-derived stem cells -- BMP bone morphogenetic protein -- BAMBI BMP and Activin membrane combined inhibitors -- BMSCs bone marrow mesenchymal stem cells -- BMPR BMP receptor -- Col 2 type II collagen -- Co-Smad common partner Smads -- DCBM decalcified cortical bone matrix -- ECM extracellular matrix -- FDCs fascia-derived cells -- GAG glycosaminoglycans -- HAp/Col transplantation of porous hydroxyapatite collagen -- HA-TA hydrogel based on a tyramine derivative of hyaluronan crosslinked by hydrogen peroxidase -- rhBMP recombinant human bone morphogenetic protein -- hBMSCs human bone marrow mesenchymal stem cells -- hMDSCs human skeletal muscle-derived stem cells -- IL-1β interleukin-1 beta -- IPFP-ASCs infrapatellar fat pad adipose stem cells -- IHH Indian hedgehog -- I-Smads inhibitory Smads -- MC-GAG nanoparticulate mineral content to collagen glycosaminoglycan -- MIA mono-iodoacetate -- MSCs mesenchymal stem cells -- NELL-1 NEL-like molecule-1 -- OA osteoarthritis -- PCL polycaprolactone -- PDCs periosteum-derived mesenchymal stem cells -- PDLSCs periodontal ligament stem cells -- PLGA l-lactide-co-glycolide -- rhBMP recombinant human bone morphogenetic protein -- R-Smads receptor-regulated Smads -- sFlt-1 soluble Flt-1 -- Smurfs Smad ubiquitination regulatory factors -- SOX-9 sex-determining region Y box gene 9 -- TGF-β transforming growth factor-beta; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Osteoarthritis -- Periodicals; Cartilage -- Periodicals; Arthrose -- Périodiques; Articulations -- Maladies -- Périodiques; 616.7223005
• DOI: 10.1016/j.joca.2018.03.007
• Languages: English
• ISSNs: 1063-4584

Abstract

Summary: Degeneration of articular cartilage (AC) tissue is the most common cause of osteoarthritis (OA) and rheumatoid arthritis. Bone morphogenetic proteins (BMPs) play important roles in bone and cartilage formation. This article reviews the experimental and clinical applications of BMPs in cartilage regeneration. Experimental evidence indicates that BMPs play an important role in protection against cartilage damage caused by inflammation or trauma, by binding to different receptor combinations and, consequently, activating different intracellular signaling pathways. Loss of function of BMP-related receptors contributes to the decreased intrinsic repair capacity of damaged cartilage and, thus, the multifunctional effects of BMPs make them attractive tools for the treatment of cartilage damage in patients with degenerative diseases. However, the development of BMP therapy as a treatment modality for cartilage regeneration has been hampered by certain factors, such as the eligibility of participants in clinical trials, financial support, drug delivery carrier safety, availabilities of effective scaffolds, appropriate selection of optimal dose and timing of administration, and side effects. Further research is needed to overcome these issues for future routine clinical applications. Research and development leading to the successful application of BMPs can initiate a new era in the treatment of cartilage degenerative diseases like OA.