Efficient Synthesis of Phthalimides via Cobalt‐Catalyzed C(sp2)−H Carbonylation of Benzoyl Hydrazides with Carbon Monoxide. Issue 17 (17th July 2018)

• Record Type: Journal Article
• Authors: Qiu, Shuxian; Zhai, Shengxian; Wang, Huifei; Tao, Cheng; Zhao, Hua; Zhai, Hongbin
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 17(2018)
• Page Start: 3271
• Page End: 3276
• Publication Date: 2018-07-17
• Subjects: Phthalimides -- Cobalt catalyst -- C−H carbonylation -- Benzoyl hydrazides -- Hydrogenolysis; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800388
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A cobalt‐catalyzed C−H carbonylation of benzoyl hydrazides has been developed by using 2‐(1‐methylhydrazinyl)pyridine as the bidentate directing group. This transformation is mild, efficient, operationally simple, and highly functional‐group‐tolerant. The protocol has generated a broad range of phthalimide derivatives in good to excellent yields. The ligand moiety can be readily removed through hydrogenolysis. Abstract :