Analysis of possible structures of inducible skin‐associated lymphoid tissue in lupus erythematosus profundus. Issue 9 (13th June 2018)

• Record Type: Journal Article
• Authors: Kogame, Toshiaki; Yamashita, Ryosuke; Hirata, Masahiro; Kataoka, Tatsuki R.; Kamido, Hisashi; Ueshima, Chiyuki; Matsui, Miho; Nomura, Takashi; Kabashima, Kenji
• Is Part Of: Journal of dermatology. Volume 45:Issue 9(2018)
• Page Start: 1117
• Page End: 1121
• Publication Date: 2018-06-13
• Subjects: ectopic lymphoid tissue -- germinal center -- inducible skin‐associated lymphoid tissue -- lupus erythematosus profundus -- tertiary lymphoid organs; Dermatology -- Periodicals; Dermatology -- Japan -- Periodicals; Skin -- Diseases -- Periodicals; 616.5005
• DOI: 10.1111/1346-8138.14498
• Languages: English
• ISSNs: 0385-2407

Abstract

Abstract: Lupus erythematosus profundus (LEP) is a variant of lupus erythematosus, involving the deep dermis and subcutaneous fat. LEP is characterized by the presence of lymphoid follicles (LF) and germinal centers (GC). However, it remains unknown whether these lymphoid structures correspond to the lymphoid tissues such as cutaneous tertiary lymphoid organs (TLO). Previously, we identified dynamically orchestrated cellular elements in murine contact dermatitis that resembled lymphoid structures, which we termed inducible skin‐associated lymphoid tissues (iSALT). We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans. Here, we studied ectopic lymphoid tissues in the lesions of LEP by immunohistochemistry and compared their characteristics with those of TLO. We demonstrated that LF of LEP were composed of B‐cell follicles intermingled with CXCL13‐expressing cells, distinct aggregations of T cells, and some blood vessels expressing peripheral node addressin. These findings indicate that LF of LEP can be considered as a type of iSALT.