PP.21.09: PERINDOPRIL, AMLODIPINE, INDAPAMIDE AND ATORAVASTATIN ADMINISTRED CONCURRENTLY IN HYPERTENSIVE AND HYPERCHOLESTEROLEMIC PTS FOSTERS A BETTER ACHIEVEMENT OF THE THERAPEUTIC TARGET. (June 2015)

• Record Type: Journal Article
• Authors: Marazzi, G.; Campolongo, G.; Pelliccia, F.; Massaro, R.; Cacciotti, C.; Quattrino, S.; Volterrani, M.; Rosano, G.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000468361.82003.58
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: In hypertensive patients not reaching the therapeutic target is considered frequent due to low compliance for the different times of therapy intake. Hence, we evaluate whether to take all antihypertensive therapy at the same time may improve compliance to treatment in order to reach a better therapeutic target. Moreover, considering that over 50% of hypertensive patients is hypercholesterolemic we also assess whether the addition of statin therapy was an obstacle to compliance. Design and method: Therefore, we have enrolled 150 hypertensive patients who were not at target with a combination therapy (2 treatment out of 3 between perindopril, amlodipine and indapamide) assessed by self-measurement at home and ambulatory blood pressure monitoring. Moreover, patients to be enrolled must also have LDL more than 115 mg / dl. All patients on top of the standard therapy were randomized 2:1: in the first group atorvastatin 20 mg was added in the evening and the missing class of antihypertensive in the morning (eg diuretic if the patient on therapy with amlodipine and perindopril) and in the second group all treatments have been intaken at the same time in the evening. After 3 months, for all included patients the following assessments have been done: ambulatory blood pressure, lipid profile and home BP self-measurement. In addition a quality of life questionnaire was administered to all patients, with particular attention to changes in nycturia. Results: At enrollment, mean BP was 144/92 mm Hg and LDL 142 mg / dl. In the first group at 3 months, the BP was 137/84 mm Hg and LDL 121 mg / dl with an average compliance of 83%, while in the second one mean BP was 132/81 mm Hg and LDL 108 mg / dl with a higher compliance (93%). In addition, the questionnaire showed no difference in comparison to baseline between the 2 groups for nycturia. Conclusions: In conclusion, statins and antihypertensive therapy combination can take to target patients, however, the best compliance in mono-administration fosters a better achievement of the therapeutic target.