PP.19.19: SERUM FERRITIN AND METABOLIC SYNDROME IN PATIENTS WITH ESSENTIAL HYPERTENSION. (June 2015)

• Record Type: Journal Article
• Authors: Vigil, L.; Lopez, M.; Castro, C. Rodriguez De; Carretero, R. Garcia; Varela, M.; Condës, E.; Alvarez, J. Garcia; Ruiz, J.
• Is Part Of: Journal of hypertension. Volume 33(2015)Supplement 1
• Publication Date: 2015-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000468298.37158.75
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Serum ferritin levels are often elevated in metabolic syndrome (MS) and are sometimes associated with a true mild-to-moderate hepatic iron overload. Our purpose was to analyse the relationship between MS and serum ferritin levels in patients with essential hypertension (EH). Design and method: Observational, crossectional study in patients with a diagnosis of EH. We measured serum ferritin and transferrin saturation index (TSI): serum-iron (μgr/dl) x 100/transferrin (mg/dl) x 1.41). MS was defined according to ATP-III criteria. Patients with type 2 DM were excluded. Results: The ferritin values did not differ between patients with/ without MS: (150 vs. 145 μgr/l, p = 0.628). The TSI was lower in patients with MS (23.5% vs. 25%, p = 0.021). The number of MS factors did not correlate with ferritin levels (r = .011, p = 0.774) but had a negative correlation with the TSI (r = -.079, p = 0.017). Ferritin levels were positively correlated with age (r = .355, p < 0.0001), haematocrit (r = .142, p < 0.0001), serum uric acid levels (r = .126, p < 0.0001), triglycerides (r = .108, p = 0.001), GGT (r = .154, p < 0.0001), GOT (r = .230, p < 0.0001), GPT (r = .268, p < 0.0001) and HOMA index (r = .107, p = 0.007) and negatively correlated with HDL-cholesterol (r = -.123, p < 0.0001) and HbA1c (r = -. 129, p < 0.0001). BMI, waist circumference and fasting glucose did not show correlations with ferritin levels. In multivariate analysis the only independent determinants of serum ferritin levels were GOT values (beta = 3.8, 95% CI: 1.5–6, p = 0.001), GGT (beta = 0.83, 95% CI: 0.30–1.36, p = 0.002), HOMA index (beta = 10.8, 95% CI: 3.7–18, p = 0.003) and HbA1c (beta = -76.8, 95% CI -116.9 to -36.7, p < 0.0001 Conclusions: In our patients with EH, the presence of MS was not associated with higher levels of serum ferritin and even showed a lower TSI. The presence of insulin resistance seems to be more related than MS to the serum ferritin levels in our hypertensive population.