13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes. (5th June 2015)

• Record Type: Journal Article
• Authors: Ferreira, M. João G.; García, A.; Leonardi, D.; Salomon, Claudio J.; Lamas, M. Celina; Nunes, Teresa G.
• Is Part Of: Carbohydrate polymers. Volume 123(2015)
• Page Start: 130
• Page End: 135
• Publication Date: 2015-06-05
• Subjects: Albendazole -- Cyclodextrin -- Inclusion complex -- Solid-state NMR; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.01.031
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Spray-dried mixtures of albendazole and cyclodextrins are studied by solid-state NMR. Different stable complexes are identified depending on the cyclodextrin substituent. Influence of cyclodextrins on albendazole solubility enhancement is explained. Abstract: 13 C and 15 N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:β-cyclodextrin, ABZ:methyl-β-cyclodextrin, ABZ:hydroxypropyl-β-cyclodextrin and ABZ:citrate-β-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.