Dynamic mechanical and swelling properties of maleated hyaluronic acid hydrogels. (5th June 2015)

• Record Type: Journal Article
• Authors: Lin, Hai; Liu, Jun; Zhang, Kai; Fan, Yujiang; Zhang, Xingdong
• Is Part Of: Carbohydrate polymers. Volume 123(2015)
• Page Start: 381
• Page End: 389
• Publication Date: 2015-06-05
• Subjects: Hydrogels -- Hyaluronic acid -- Mechanical property -- Swelling kinetics -- Photopolymerization; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2015.01.047
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: A novel hyaluronic acid modification method was developed. DS of maleated hyaluronan (MaHA) is higher than methacrylated hyaluronan's (MeHA). The hydrogels of MaHA have higher compressive storage moduli than those of MeHA. The crosslinking density and hydrophilicity of introduced groups affect the swelling. Abstract: A series of maleated hyaluronan (MaHA) are developed by modification with maleic anhydride. The degrees of substitution (DS) of MaHA vary between 7% and 75%. The DS of MaHA is both higher and wider than methacrylated HA derivatives (MeHA) reported in the literature. MaHA hydrogels are then prepared by photopolymerization and their dynamic mechanical and swelling properties of the hydrogels are investigated. The results showed that MaHA hydrogels with moderate DS (25%, 50% and 65%) have higher storage modulus and lower equilibrium swelling ratios than those with either low or high DS (7%, 15% and 75%). Theoretical analyses also suggest a similar pattern among hydrogels with different DS. The results confirm that the increased cross-linking density enhances the strength of hydrogels. Meanwhile, the hydrophilicity of introduced groups during modification and the degree of incomplete crosslinking reaction might have negative impact on the mechanical and swelling properties of MaHA hydrogels.