Comparative Morbidity Outcomes in Live Kidney Donors in the UK: 15 Year Cohort Study. (July 2018)

• Record Type: Journal Article
• Authors: Krishnan, Nithya Santhana; Mumford, Lisa; Lipkin, Graham; Fletcher, Simon; Dasgupta, Indranil; Gill, Paramjit; Ryan, Ronan; Raymond, Neil
• Is Part Of: Transplantation. Volume 102(2018)Supplement 7S-1
• Publication Date: 2018-07
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/01.tp.0000542754.27911.75
• Languages: English
• ISSNs: 0041-1337

Abstract

Abstract : Aim: To investigate longer term morbidity outcomes of U.K live kidney donors (LD) compared to with a healthy controls. Methods: Ethics approval was already in place to accrue data from datatbase. Study protocol was reviewed and passed by Renal Registry projects advisory group, and an independent scientific review committee, before release of the data. Cohorts for Study: A) Live Donors (LD) dataset: Dataset obtained from the UK Transplant Registry held by National Health Service Blood and Transplant, U.K. All live kidney donors from January 1st 2001 to 31st December, 2013 included and the end date was 31st December 2016. B) Comparative Cohort, The Health Improvement Network (THIN) database: This is a large UK general practice database which contains anonymized longitudinal patient records from over 500 practices. Data from THIN was collected stratified by age, gender and year of entry to provide a comparative cohort excluding a number of baseline conditions that would have been a contraindication to donation. Results: Table 1 shows baseline characteristics of LD and THIN. Figure 1 shows statistically significant increase in cardiovascular disease, diabetes and depression in the THIN cohort, and proteinuria in the LD group. Hypertension, though significantly higher in the LD group in the initial years, after seven years was significantly lower, possibly due to healthy lifestyle, regular follow up and early intervention. There were no cases of end stage renal disease (ESRD) in the LD group whereas 17 cases in THIN (P=0.01). Extending the analysis to include eGFR <30, there were 8 cases in the LD group when compared to 94 in THIN (P<0.001). Figure. No caption available. Conclusions: Though hypertension was significantly more common in the LD group in the early years when compared with a healthy matched cohort, the prevalence of hypertension after about seven years was lower in the LD group. In this analysis live kidney donors seemed to have better long-term health outcomes than matched controls. Warwickshire Private Hospitals Charity Fund. Coventry Kidney Research Fund.