Islet Identity in Patients with Pancreatitis. (July 2018)

• Record Type: Journal Article
• Authors: Sabek, Omaima; Beamish, Christine; Fraga, Daniel; Gaber, A Osama
• Is Part Of: Transplantation. Volume 102(2018)Supplement 7S-1
• Publication Date: 2018-07
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; Transplantation immunology -- Periodicals; 617.95
• DOI: 10.1097/01.tp.0000543743.33466.64
• Languages: English
• ISSNs: 0041-1337

Abstract

Abstract : Objective: Total pancreatectomy (TP) and islet auto-transplantation (IAT) is a treatment for chronic pancreatitis; however, its projected success largely relies on transplanted islet equivalent, and defined by post-surgical insulin-injection independence and HbA1c. Endocrine-cell dedifferentiation has been suggested to contribute to metabolic failure in type 2 diabetes, shown by the co-localization of insulin with glucagon and/or vimentin. Here, we correlate islet phenotypic identity with pre- and post-surgical metabolic function following TPIAT in two patients. Research Design and Methods: Metabolic function was compared with histological assessment of endocrine cells demonstrating variable co-expression of insulin and glucagon. Results: Patient 1 demonstrated high endocrine cellular phenotypic maintenance and remained insulin-injection free at study completion. Conclusion: Endocrine-cell dedifferentiation was identified prior to TPIAT, which correlated with pre- and post-surgical endocrine function and transplant endpoints, and may contribute as a predictor of interventional success. Vivian Smith Foundation. Brown Foundation.