An iridium complex-based probe for photoluminescence lifetime imaging of human carboxylesterase 2 in living cells. Issue 65 (26th July 2018) - Yan, Zihe
Abstract : Human carboxylesterase 2 is detected and imaged in living cells using a photoluminescence lifetime probe for the first time. Abstract : A novel photoluminescence lifetime probe (Ir-TB) has been developed for the detection and imaging of hCE2 in living cells. A large lifetime increase by around 300 ns after the enzymatic reaction makes it an ideal tool to distinguish hCE2-hydrolyzed probes from those non-hydrolyzed ones via PLIM for the first time.