Post‐influenzal triazole‐resistant aspergillosis following allogeneic stem cell transplantation. Issue 8 (11th June 2018)

• Record Type: Journal Article
• Authors: Talento, Alida Fe; Dunne, Katie; Murphy, Niamh; O'Connell, Brian; Chan, Grace; Joyce, Eimear Ann; Hagen, Ferry; Meis, Jacques F.; Fahy, Ruairi; Bacon, Larry; Vandenberge, Elisabeth; Rogers, Thomas R.
• Is Part Of: Mycoses. Volume 61:Issue 8(2018)
• Page Start: 570
• Page End: 575
• Publication Date: 2018-06-11
• Subjects: influenza -- invasive pulmonary aspergillosis -- stem cell transplant -- triazole resistance; Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.12770
• Languages: English
• ISSNs: 0933-7407

Abstract

Summary: Influenza virus infection is now recognised as a risk factor for invasive pulmonary aspergillosis (IPA). Delays in diagnosis contribute to delayed commencement of antifungal therapy. In addition, the emergence of resistance to first‐line triazole antifungal agents puts emphasis on early detection to prevent adverse outcomes. We present 2 allogeneic stem cell transplant patients who developed IPA due to triazole‐resistant Aspergillus fumigatus following influenza infection. We underline the challenges faced in the management of these cases, the importance of early diagnosis and need for surveillance given the emergence of triazole resistance.