Nitro sulfonyl fluorides are a new pharmacophore for the development of antibiotics. Issue 4 (13th June 2018)

• Record Type: Journal Article
• Authors: Sadlowski, Corinne; Park, Bora; Araujo Borges, Clarissa; Das, Subhamoy; Lucas Kerr, D.; He, Maomao; Han, Hesong; Riley, Lee; Murthy, Niren
• Is Part Of: Molecular Systems Design and Engineering. Volume 3:Issue 4(2018)
• Page Start: 599
• Page End: 603
• Publication Date: 2018-06-13
• Subjects: Chemistry -- Molecular aspects -- Periodicals; Chemical engineering -- Molecular aspects -- Periodicals; Nanotechnology -- Periodicals; 620.5
• DOI: 10.1039/c8me00011e
• Languages: English
• ISSNs: 2058-9689

Abstract

Abstract : The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. Abstract : The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa .