Detection of bisphenol A and derivatives in human urine via cyclodextrin-promoted fluorescence modulation. Issue 30 (18th July 2018)

• Record Type: Journal Article
• Authors: DiScenza, Dana J.; Lynch, Julie; Feder, Ezra; Levine, Mindy
• Is Part Of: Analytical methods. Volume 10:Issue 30(2018)
• Page Start: 3783
• Page End: 3790
• Publication Date: 2018-07-18
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/c8ay00733k
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : Reported herein is the first application of cyclodextrin-promoted fluorescence modulation for the detection of bisphenol A and its derivatives in human urine. Abstract : Reported herein is the sensitive and selective detection of bisphenol A (BPA) and six BPA derivatives in buffer and urine environments. This detection system relies on the ability of γ-cyclodextrin to act as a supramolecular scaffold to promote highly analyte-specific, proximity-induced fluorescence modulation of high quantum yield fluorophores, which led to unique modulation responses for each cyclodextrin–analyte–fluorophore combination investigated in both buffer and urine environments, and high selectivity between structurally similar analytes using linear discriminant analysis of the resulting response signals. This method was sensitive (low micromolar detection limits), selective (able to differentiate between structurally similar analytes), and broadly applicable (with successful detection in both buffer and urine environments), and has significant potential in the detection of BPA and its derivatives in a wide variety of complex environments.