ACUTE EFFECT OF COFFEE ON AORTIC STIFFNESS AND WAVE REFLECTIONS IN HEALTHY INDIVIDUALS: DIFFERENTIAL EFFECT ACCORDING TO HABITUAL CONSUMPTION. (June 2018)

• Record Type: Journal Article
• Authors: Ioakeimidis, N.; Tzifos, V.; Terentes-Printzios, D.; Georgakopoulos, C.; Skliros, N.; Koutagiar, I.; Pantou, S.; Vlachopoulos, C.; Tousoulis, D.
• Is Part Of: Journal of hypertension. Volume 36(2018)Supplement 1
• Publication Date: 2018-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000539340.07506.be
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract: Objective: Coffee and caffeine given alone acutely increase aortic stiffness and wave reflections, however, there are no studies investigating the influence of habitual vs non-habitual coffee consumption in this effect. Therefore, the present study was undertaken to investigate whether the acute effect of coffee or caffeine on aortic stiffness is different between habitual and non-habitual coffee consumers. Design and method: The acute effect of coffee on arterial stiffness and its dependence on habitual consumption was studied in 24 volunteers on four separate occasions during which subjects received: a) coffee espresso, b) decaffeinated coffee espresso, c) caffeine alone and d) placebo (hot water). Results: The increase in carotid femoral pulse wave velocity (PWV), augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform after coffee consumption was more pronounced in non-habitual (n = 13) compared to habitual drinkers (n = 11), (differences of maximal changes between groups in PWV, AIx, AP responses by 0.39 m/s, 4.5% and 1.9 mmHg, respectively, for coffee; and by 0.34 m/s, 5.3% and 2.1 mmHg, respectively, for decaffeinated coffee; all p < 0.05). Caffeine increased PWV, as well as AIx and AP but differences in responses between the two groups were not significant. Conclusions: Both caffeinated and decaffeinated coffee consumption is associated with a more potent effect on arterial stiffness in non-habitual than habitual coffee consumers, whereas caffeine induces comparable changes in both groups.