THE ASSOCIATION BETWEEN CAROTID FLOW AND COGNITIVE FUNCTION IN THE COMMUNITY ELDERLY POPULATION. (June 2018)

• Record Type: Journal Article
• Authors: Chuang, S.Y.; Cheng, H.M.; Yip, B.S.; Chen, C.H.; Pan, W.H.
• Is Part Of: Journal of hypertension. Volume 36(2018)Supplement 1
• Publication Date: 2018-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000539227.11146.2f
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Carotid hemodynamics, such as intima-media thickness and carotid flow velocity were associated with stroke events. However, the association between carotid hemodynamics and cognitive function remains not fully clear. We aimed to investigate the relationship between carotid flow velocity and cognitive function. Design and method: A total of 744 elderly (more than 60 years) subjects completed the baseline and followed ultrasound examinations and those were evaluated cognitive function. Cognitive function was evaluated by MMSE and cognitive function impairment was defined by the MMSE less than 26. The peak-systolic velocity, end-diastolic velocity were measured in the common carotid arteries. Logistic regression was used to evaluate the association between carotid flow velocities, carotid diameters and cognitive function. Results: A total of 744 elderly subjects completed all examinations during the followed period. The prevalence Cognitive function impairment (MMSE less than 26) was 13.3% (n = 99). The peak systolic velocity (PSV) and diastolic end velocity (EDV) were lower in those with cognitive function impairment (60.5 vs. 65.5 cm/sec, p-value < 0.001 for PSV and 19.7 vs. 22.1 cm/sec, p-value < 0.001 for EDV), and only peak-systolic velocity remains significant in the multivariable models. Moreover, those with lower carotid flow velocities (the lowest 10th of peak systolic velocity) had 9.69 fold risk (95% confidence intervals: 2.75–34.21) of cognitive function impairment, compared to those with the highest 10th of peak systolic velocity. The significant association remains in the multivariable model by adjusting for age, gender, education, brachial systolic BP, fasting glucose, and low density lipoprotein cholesterol. Conclusions: Low carotid flow velocity, especially peak-systolic velocity was associated with cognitive function impairment. Lower carotid flow may involve the pathogen of cognitive function impairment in the general elderly population.