Multilayer Bacteriostatic Coating for Surface Modified Titanium Implants. Issue 15 (22nd March 2018)

• Record Type: Journal Article
• Authors: Vögeling, Hendrik; Duse, Lili; Seitz, Benjamin Sebastian; Plenagl, Nikola; Wojcik, Matthias; Pinnapireddy, Shashank Reddy; Bakowsky, Udo
• Other Names: Wagner Patrick guestEditor.; Keusgen Michael guestEditor.; Doll Theodor guestEditor.; Wagner Torsten guestEditor.; Schöning Michael J. guestEditor.
• Is Part Of: Physica status solidi. Volume 215:Issue 15(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-03-22
• Subjects: antiadhesive -- antibacterial -- layer by layer -- surface modification -- titanium implants; Solid state physics -- Periodicals; Solids -- Industrial applications -- Periodicals; 530.41
• DOI: 10.1002/pssa.201700844
• Languages: English
• ISSNs: 1862-6300

Abstract

Abstract : One of the serious problems occurring after the insertion of implants is the formation of biofilms. This leads to implant loss or sepsis. The multilayer coating developed in this study addresses the problems pertaining to bacterial growth and biofilm formation by two different approaches viz. preventing bacterial adhesion by nanostructured surface modification and by modification of the titanium surface by creating an ultra‐thin poly(lactic‐co‐glycolic acid) (PLGA)/norfloxacin (NFX) nanoparticle coating. In this study, NFX loaded PLGA nanoparticles are used to coat titanium surfaces using the layer by layer method alternating with chitosan. The advantages of biodegradable polymers like PLGA and chitosan to create an anti‐adhesive and antibacterial coating are utilised. The polymers in this study show a high biocompatibility and are completely degraded within 10 weeks which makes them an excellent choice for use in dental implants and stents. Abstract : The multilayer coating developed in this study addresses the problems associated with bacterial growth and biofilm formation by two different approaches viz. preventing bacterial adhesion by nanostructured surface modification and by creating an ultra‐thin PLGA/norfloxacin nanoparticle coating on the titanium/implant surface. Multi‐layered norfloxacin loaded PLGA nanoparticles alternating with chitosan are used to coat titanium surfaces.