EFFECT OF SALT INTAKE ON PLASMA AND URINARY URIC ACID LEVELS IN CHINESE ADULTS: AN INTERVENTIONAL TRIAL. (June 2018)

• Record Type: Journal Article
• Authors: Wang, Y.; Chu, C.; Wang, K.-K.; Hu, J.-W.; Yan, Y.; Lv, Y.-B.; Cao, Y.-M.; Zheng, W.-L.; Dang, X.-L.; Xu, J.-T.; Chen, W.; Yuan, Z.-Y.; Mu, J.-J.
• Is Part Of: Journal of hypertension. Volume 36(2018)Supplement 1
• Publication Date: 2018-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000539339.99882.e6
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract: Objective: Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess the effects of altered salt intake on plasma and urine UA levels and the relationship between UA levels and salt sensitivity in humans. Design and method: Ninety subjects (18–65 years old) were selected from a rural community in Northern China in our interventional study. All subjects were sequentially maintained on a normal diet for 3 days at baseline, on a low-salt diet for 7 days (3.0 g/day, NaCl), and on a high-salt diet for an additional 7 days (18.0 g/day of NaCl). Results: Plasma UA levels significantly increased from baseline to low-salt diet (262.7 ± 7.6 vs. 280.0 ± 7.4 μmol/L, P < 0.001) and decreased from low-salt to high-salt diet (280.0 ± 7.4 vs. 242.6 ± 7.1 μmol/L, P < 0.001). By contrast, daily urinary levels of UA significantly decreased from baseline to low-salt diet (2, 242.4 ± 168.3 vs. 1, 558.2 ± 101.1 μmol/24 h, P < 0.001) and increased from low-salt to high-salt diet (1, 558.2 ± 101.1 vs. 1, 761.9 ± 90.2 μmol/24 h, P = 0.032). The 24 h urinary sodium excretions showed inverse correlation with plasma UA (r = −0.258, P < 0.001) and positive correlation with urinary UA excretions (r = 0.176, P = 0.019). Additionally, as shown in Figure, salt-sensitive subjects presented significantly higher plasma UA changes in comparison to salt-resistant subjects (low salt response: 34.9 ± 7.8 vs. 12.5 ± 4.8 μmol/L, P = 0.028; high salt response: −52.5 ± 7.7 vs. −33.4 ± 4.1 μmol/L, P = 0.034), and a negative correlation was observed between degree of salt sensitivity and plasma UA difference. Figure. No caption available. Conclusions: The present study indicates that variations in dietary salt intake affect plasma and urine UA levels, and plasma UA may be involved in the pathophysiological process of salt sensitivity.