THE IMPACT OF MASKED AND WHITE COAT HYPERTENSION ON APELIN AND RELAXIN PLASMA LEVELS. (June 2018)

• Record Type: Journal Article
• Authors: Papadopoulos, D.P.; Sanidas, E.; Zerva, K.; Velliou, M.; Tsakalis, C.; Korrou, E.; Matzourani, M.; Barbetseas, J.
• Is Part Of: Journal of hypertension. Volume 36(2018)Supplement 1
• Publication Date: 2018-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000539578.91747.28
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Objective: Recent evidence demonstrates that masked hypertension (MH) is a significant predictor of cardiovascular disease, while white-coat hypertension (WCH) a common phenomenon is associated with impaired endothelial function, increased cardiovascular risk and is considered as a prognostic marker for the development of established hypertension. Hypoapelinemia and hyporelaxinemia may contribute to vascular damage accelerating atherogenesis. Aim of our study was to examine the apelin and relaxin plasma levels in patients with MH and compare the findings to those with white coat effect matched for age, sex, body mass index and the rest of risk fact Design and method: Our findings and the comparisons between the two groups are shown in the table below. Results: Out off one hundred-thirty (60 M, 70 F) healthy subjects mean age 45 ± 12 underwent 24 hour ambulatory blood pressure monitoring (ABPM), 24 individuals (8 M, 16 F) had MH (daytime systolic blood pressure 135 mmHg or daytime diastolic blood pressure 85 mmHg - group A) and 32 healthy subjects (20 M, 12F, ) had WCH. Apelin and relaxin plasma levels were determined in both groups (ELISA method). Results: Results: Our findings and the comparisons between the two groups are shown in the table below: Group A (n = 24) Group B (n = 32) p Apelin (pg/ml) 200 ± 111 305 ± 127 <0.01 Relaxin (pg/ml) 35, 2 ± 6, 7 46.8 ± 23.6 <0.01 Conclusions: Our findings suggest that subjects with MH have significantly lower apelin and relaxin levels compared to WCH individuals. This observation may have prognostic significance for future cardiovascular events in subjects with MH compared toWCH subjects and needs further investigation.