IMPACT OF AGE ON THE ASSOCIATIONS BETWEEN TARGET ORGAN DAMAGE AND HEMODYNAMIC COMPONENTS DERIVED FROM 24-HOUR AMBULATORY BLOOD PRESSURE MEASUREMENT. (June 2018)

• Record Type: Journal Article
• Authors: Olesen, T.; Pareek, M.; Stidsen, J.; Blicher, M.; Rasmussen, S.; Vishram-Nielsen, J.; Olsen, M.
• Is Part Of: Journal of hypertension. Volume 36(2018)Supplement 1
• Publication Date: 2018-06
• Subjects: Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/01.hjh.0000539433.80857.69
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Hemodynamic parameters obtained from 24-hour ambulatory blood pressure (BP) measurements (24hABPM) are more closely associated with markers of target organ damage than conventional office BP. The aim of this study was to evaluate the impact of age on the associations between hemodynamic components derived from 24hABPM and target organ damage, in apparently healthy, non-medicated subjects. Design and method: 24hABPM and target organ damage (left ventricular mass index, pulse wave velocity, urine albumin:creatinine ratio and carotid atherosclerotic plaques) were evaluated in 1408 subjects. Associations were examined in regression models, stratified for age [middle-aged (41 or 51 years) or elderly (61 or 71 years)], and adjusted for sex, smoking status, and total-cholesterol. Results: In middle-aged subjects, an increase of 10 mmHg in 24-hour systolic blood pressure was independently associated with an increase of 3.8 (2.7–4.8) g/m2 in LVMI. The effect was nearly doubled in the elderly subgroup, where the same increase resulted in an increase in LVMI of 6.3 (5.0–7.6) g/m2 (P for interaction < 0.01). An increase of 10 mmHg of 24-hour systolic blood pressure was associated with a 6.5% increase in pulse wave velocity in middle-aged subjects and with an 8.9% increase in elderly subjects (P for interaction < 0.01). An independent association between 24hABPM and urine albumin:creatinine ratio was only observed in the elderly subgroup. Associations between the presence of atherosclerotic plaques and components from 24hABPM, except that for 24hDBP, were not modified by age (P for all interactions > 0.26). Conclusions: Age enhances the associations between hemodynamic components obtained from 24hABPM and measures of arterial stiffness, microvascular damage, and cardiac structure, but not atherosclerosis.