Curvature‐Induced Sorting of Lipids in Plasma Membrane Tethers. Issue 8 (5th June 2018)

• Record Type: Journal Article
• Authors: Baoukina, Svetlana; Ingólfsson, Helgi I.; Marrink, Siewert J.; Tieleman, D. Peter
• Is Part Of: Advanced theory and simulations. Volume 1:Issue 8(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-06-05
• Subjects: bilayer nanotubes -- cellular trafficking -- curvature sensing -- molecular shape -- transport intermediates; Science -- Simulation methods -- Periodicals; Science -- Methodology -- Periodicals; Engineering -- Simulation methods -- Periodicals; Engineering -- Methodology -- Periodicals; 507.21
• DOI: 10.1002/adts.201800034
• Languages: English
• ISSNs: 2513-0390

Abstract

Abstract: Membrane curvature controls the spatial organization and activity of cells. Lipid sorting in cell membranes can be explained by matching lipid molecular shape to regions of different curvatures. A molecular view of curvature‐induced lipid sorting is obtained using coarse‐grained molecular dynamics. A model membrane consisting of an asymmetric bilayer of multiple lipid species is simulated. Curvature is induced by pulling a tether, that is, a bilayer nanotube, from a flat membrane. Pulling is performed both from the inner and outer leaflets, corresponding to directions in and out of the cell. Redistribution of different lipid types between the tether and the bilayer is observed, leading to spatial variations in the composition of both leaflets, and, in turn, softening of the tether. Depending on the direction of pulling, the lipid distributions and the tether properties differ. Formation of a tether from the planar membrane thus induces lipid sorting without phase separation. Abstract : A curvature‐induced lipid sorting on pulling a tether from an idealized plasma membrane is observed in coarse‐grained simulations. Lipid sorting occurs in the absence of proteins or a phase separation, depends on pulling direction and leads to softening of the tether. The sorting can be explained by the effective shape and chain saturation of the lipid molecules.