Front Cover: Platelet Releasate Proteome Profiling Reveals a Core Set of Proteins with Low Variance between Healthy Adults. Issue 15 (8th August 2018)

• Record Type: Journal Article
• Authors: Parsons, Martin E. M.; Szklanna, Paulina B.; Guerrero, Jose A.; Wynne, Kieran; Dervin, Feidhlim; O'Connell, Karen; Allen, Seamus; Egan, Karl; Bennett, Cavan; McGuigan, Christopher; Gheveart, Cedric; Ní Áinle, Fionnuala; Maguire, Patricia B.
• Is Part Of: Proteomics. Volume 18:Issue 15(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-08
• Subjects: Proteins -- Separation -- Periodicals; Bioinformatics -- Periodicals; Proteomics -- Periodicals; Genomes -- Periodicals; Molecular genetics -- Periodicals; 572.605
• DOI: 10.1002/pmic.201870131
• Languages: English
• ISSNs: 1615-9853

Abstract

Abstract : DOI:10.1002/pmic.201800219 Upon activation, platelets release a powerful cocktail of soluble and vesicular signals, collectively termed the 'platelet releasate'. In article number 1800219, Parsons et al. use label‐free quantitative (LFQ)‐proteomics analysis to provide a reproducible, quantifiable investigation of the platelet releasate from 32 healthy adults. Their results show that the platelet releasate has low‐population variance among healthy adults, rendering it a potentially useful platform for diagnostic fingerprinting of platelet‐related disease.