A Palladium‐Catalyzed Domino Procedure for the Synthesis of Unsymmetrical Ureas. Issue 15 (14th June 2018)

• Record Type: Journal Article
• Authors: Chen, Bo; Peng, Jin‐Bao; Ying, Jun; Qi, Xinxin; Wu, Xiao‐Feng
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 15(2018)
• Page Start: 2820
• Page End: 2824
• Publication Date: 2018-06-14
• Subjects: Cascade reaction -- Unsymmetrical urea -- Carbonylation -- Curtius rearrangement -- Palladium catalyst; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800496
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A palladium‐catalyzed carbonylative procedure for the synthesis of unsymmetrical ureas has been developed. This one‐pot one‐step cascade procedure is consisted by three individual processes: carbonylation, Curtius rearrangement, and nucleophilic addition. A series of unsymmetrical ureas were prepared from easily available aryl iodides and amines in moderate to excellent yields. This procedure provides a convenient and practical approach for unsymmetrical urea synthesis. Abstract :