Frontispiece: A Cyclometalated IrIII Complex as a Lysosome‐Targeted Photodynamic Therapeutic Agent for Integrated Imaging and Therapy in Cancer Cells. Issue 43 (1st August 2018)

• Record Type: Journal Article
• Authors: Sudheesh, Karivachery V.; Jayaram, Prasad S.; Samanta, Animesh; Bejoymohandas, Kochan S.; Jayasree, Ramapurath S.; Ajayaghosh, Ayyappanpillai
• Is Part Of: Chemistry. Volume 24:Issue 43(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-08-01
• Subjects: apoptosis -- cell imaging -- lysosomes -- singlet oxygen -- theranostic agents; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201884365
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Organelle‐targeted photosensitizers with luminescence properties are potential theranostic agents for simultaneous imaging and photodynamic therapy. Described herein is a cyclometalated Ir III complex, Ir‐Bp‐Ly, that exhibits high triplet quantum yield and singlet‐oxygen‐generation efficiency. The close‐proximity energy levels between triplet energy states of Ir‐Bp‐Ly and molecular oxygen favors efficient singlet oxygen and reactive oxygen species (ROS) generation. The good lysosomal specificity of Ir‐Bp‐Ly leads to its increased efficacy as a photodynamic therapeutic and imaging agent. More information can be found in the Full Paper by A. Ajayaghosh et al. onpage 10999 ff.