Rescue haploidentical peripheral blood stem cell transplantation for engraftment failure: a single‐centre case series. Issue 8 (7th August 2018)

• Record Type: Journal Article
• Authors: Kliman, David; Bilmon, Ian; Kwan, John; Blyth, Emily; Micklethwaite, Ken; Panicker, Shyam; Bhattacharyya, Abir; Deren, Stephanie; Antonenas, Vicki; Huang, Gillian; Gottlieb, David
• Is Part Of: Internal medicine journal. Volume 48:Issue 8(2018)
• Page Start: 988
• Page End: 991
• Publication Date: 2018-08-07
• Subjects: allogeneic stem cell transplant -- graft failure -- haploidentical transplant -- peripheral blood stem cells -- graft‐versus‐host disease; Medicine -- Periodicals; 616
• DOI: 10.1111/imj.13979
• Languages: English
• ISSNs: 1444-0903

Abstract

Abstract: Graft failure affects approximately 5% of allogeneic stem cell transplants, with a poor prognosis. Salvage second allogeneic stem cell transplantation (alloSCT2) is limited by high rates of transplant‐related mortality from infection and graft‐versus‐host disease. We report on five adult patients receiving rescue alloSCT2 using haploidentical peripheral blood stem cells. All patients achieved neutrophil engraftment, two subsequently died from sepsis and disease relapse, respectively. Three patients remain alive up to 2 years post‐transplant. We suggest consideration of haploidentical alloSCT2 for patients with graft failure.