Manganese‐Catalyzed C−H Amidation of Heteroarenes in Water. Issue 15 (12th June 2018)

• Record Type: Journal Article
• Authors: Kong, Xianqiang; Lin, Long; Xu, Bo
• Is Part Of: Advanced synthesis & catalysis. Volume 360:Issue 15(2018)
• Page Start: 2801
• Page End: 2805
• Publication Date: 2018-06-12
• Subjects: C−H activations -- manganese -- directing group -- amidation; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201800544
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: We have developed an efficient manganese‐catalyzed amidation of various heteroarenes via C−H bond activation using readily available sulfonyl azides. The key step is heteroarene directed electrophilic aromatic metalation using MnBr(CO)5 as catalyst. This method offers excellent chemical yields and regioselectivity with good functional group tolerance. This base metal catalyzed reaction proceeds efficiently using water as the only solvent and nitrogen is the only byproduct. Abstract :