Bioimaging: Dual‐Modal NIR‐Fluorophore Conjugated Magnetic Nanoparticle for Imaging Amyloid‐β Species In Vivo (Small 28/2018). Issue 28 (12th July 2018)

• Record Type: Journal Article
• Authors: Li, Yinhui; Xu, Di; Chan, Hei‐Nga; Poon, Chung‐Yan; Ho, See‐Lok; Li, Hung‐Wing; Wong, Man Shing
• Is Part Of: Small. Volume 14:Issue 28(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-07-12
• Subjects: Alzheimer's disease -- amyloid‐β -- dual‐modal imaging -- fluorescence -- MRI; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201870130
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : In article number1800901, Hung‐Wing Li, Man‐Shing Wong, and co‐workers report a smart NIR/MR dual‐modal nano‐probe for in vivo imaging of β ‐amyloid in a Alzheimer's Disease transgenic mouse model. This nanoparticle‐based probe is not only non‐radiative and non‐toxic, but also highly blood brain barrier permeable and neuroprotective against A β induced toxicities, suggesting a great potential for early detection and diagnosis of Alzheimer's disease in humans.