Inflammatory markers and suicidal attempts in depressed patients: A review. (December 2016)

• Record Type: Journal Article
• Authors: Marini, Stefano; Vellante, Federica; Matarazzo, Ilaria; De Berardis, Domenico; Serroni, Nicola; Gianfelice, Daniela; Olivieri, Luigi; Di Renzo, Fulvia; Di Marco, Anna; Fornaro, Michele; Orsolini, Laura; Valchera, Alessandro; Iasevoli, Felice; Mazza, Monica; Perna, Giampaolo; Martinotti, Giovanni; Di Giannantonio, Massimo
• Is Part Of: International journal of immunopathology and pharmacology. Volume 29:Number 4(2016)
• Page Start: 583
• Page End: 594
• Publication Date: 2016-12
• Subjects: inflammatory markers -- major depressive disorder -- suicidal attempts; Immunopathology -- Periodicals; Pharmacology -- Periodicals; Inflammation -- Periodicals; 615.1
• DOI: 10.1177/0394632015623793
• Languages: English
• ISSNs: 0394-6320

Abstract

Major depressive disorder is a chronic and invalidating psychiatric illness and is associated with a greater risk of suicidal behaviors. In recent decades many data have supported a biological link between depressive states and inflammation. Pro-inflammatory cytokines have been found to rise, first of all TNF-α and IL-6. Suicidal behaviors have been consistently associated with increased levels of IL-6 and decreased levels of IL-2. The aim of this review is to investigate the relationship between inflammatory markers in depressed patients with or without suicidal attempts compared to healthy controls.