In Vivo Laser Confocal Microscopy Using the HRT-Rostock Cornea Module: Diversity and Diagnostic Implications in Patients with Uveitis. (18th August 2018)

• Record Type: Journal Article
• Authors: Lim, Lyndell L.; Xie, Jing; Chua, Chyn C.; Wong, Tiffany; Hoang, Lani T.; Becker, Matthias D.; Suhler, Eric B.; Rosenbaum, James T.; Mackensen, Friederike
• Is Part Of: Ocular immunology and inflammation. Volume 26:Number 6(2018)
• Page Start: 900
• Page End: 909
• Publication Date: 2018-08-18
• Subjects: Confocal microscopy -- imaging analysis -- keratic precipitates -- uveitis; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.1080/09273948.2017.1298818
• Languages: English
• ISSNs: 0927-3948

Abstract

Abstract: Purpose : Keratic precipitates (KP) are a common feature of uveitis. We prospectively examined KP with the Heidelberg Retinal Tomograph II confocal laser scanning microscope and Rostock Corneal Module (HRT-RCM) to explore their diagnostic implications. Methods : Prospective, observational, multicenter study. HRT-RCM images were classified by two masked observers. Results : 120 scans on 120 eyes from 110 subjects were included. The majority ( N = 93) had non-infectious uveitis. Sixty eyes had active disease at scanning. Eight KP morphologies were defined. Agreement between the two masked graders was high (Kappa value across all categories = 0.81). Cluster and nodular KP were associated with active infectious uveitis (p < 0.01): patients with cluster KP (odds ratio [OR] = 3.03, 95% confidence interval [CI]: 1.43, 6.45) and nodular KP (OR = 3.89, 95% CI: 1.42, 10.65) were more likely to have infectious uveitis than those without. Conclusions : Laser confocal microscopy of KP may have a role in determining between infectious and non-infectious uveitis.