Carborane and cyanine conjugated galactose targeted amphiphilic copolymers for potential near infrared imaging-guided boron neutron capture therapy (BNCT). Issue 12 (13th August 2018)

• Record Type: Journal Article
• Authors: Ruan, Zheng; Yuan, Pan; Liu, Le; Xing, Tao; Yan, Lifeng
• Is Part Of: International journal of polymeric materials. Volume 67:Issue 12(2018)
• Page Start: 720
• Page End: 726
• Publication Date: 2018-08-13
• Subjects: Bioimaging -- boron neutron capture therapy -- copolymer -- m-carborane -- near infrared fluorescence; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2017.1376199
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: Near infrared fluorescent galactose targeted glycopolymer containing m -carborane has been synthesized through ring open and atom transfer radical polymerization, followed by post-functionalization with a cyanine NIR dye. The copolymer could self-assemble into micelles which work as a potential agent for imaging-guided boron neutron capture therapy. The NIR micelles revealed no cytotoxicity for HepG2 cells. An enhanced and fast endocytosis due to the specific interaction between the HepG2 cells and the glycopolymer could be traced by fluorescence microscopy, and the bioimaging makes it possible to trace the nanoparticles and provides information where and when the neutron irradiation should be triggered. GRAPHICAL ABSTRACT: