Delivery of cisplatin by folic acid-targeted liposomal nanoparticles into liver cancer cell line. Issue 14 (22nd September 2018)

• Record Type: Journal Article
• Authors: Foroud, Niki; Ardjmand, Mehdi; Heidarinasab, Amir; Akbarzadeh, Azim
• Is Part Of: International journal of polymeric materials. Volume 67:Issue 14(2018)
• Page Start: 865
• Page End: 872
• Publication Date: 2018-09-22
• Subjects: Cisplatin -- folic acid -- liposome -- liver cancer -- polyethylene glycol; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2017.1393676
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: This study aimed to prepare cisplatin-loaded PEGylated liposomal nanoparticles targeted with folic acid and evaluate their efficacy on liver cancer cell line PLC/PRF/5 (Alexander hepatoma cell line). Nanoparticles were prepared by reverse phase evaporation technique and characterized by dynamic light scattering, scanning electron microscopy, transmission electron microscopy, inductively coupled plasma optical emission spectrometry, Fourier transform infrared spectroscopy, and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide techniques. Nanoscale particles with appropriate drug encapsulation efficiency (13%) were prepared. Cytotoxicity results indicated that the superior potency of targeted cisplatin-loaded nanoparticles compared to the nontargeted counterpart with 23% more cytotoxicity. Findings of this study confirmed the potency of targeted PEGylated liposomal nanoparticles. GRAPHICAL ABSTRACT: