Preoperative computed tomography and serum α-fetoprotein to predict microvascular invasion in hepatocellular carcinoma. Issue 27 (July 2018)

• Record Type: Journal Article
• Authors: Zhang, Wei; Liu, Lijuan; Wang, Peng; Wang, Lili; Liu, Lidong; Chen, Jie; Su, Danke
• Other Names: Augustin. Goran section editor.
• Is Part Of: Medicine. Volume 97:Issue 27(2018)
• Publication Date: 2018-07
• Subjects: α-fetoprotein -- computed tomography -- hepatocellular carcinoma -- microvascular invasion; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000011402
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract : Abstract: To determine the diagnostic value of computed tomography (CT) for prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC). Preoperative CTs for 160 patients with 57 MVI-positive and 103 MVI-negative HCCs diagnosed by surgical pathology were reviewed retrospectively. CT parameters and serum α-fetoprotein (AFP) level were analyzed in SPSS 16.0. Although univariate analysis showed that tumor size ( P = .012), grade (Z = −2.114, P = .034), and peritumoral enhancement (χ 2 = 4.464, P = .035) were associated with MVI, multiple logistic regression analysis showed that capsular invasion (odds ratio [OR] = 23.469, P < .001), margins (OR = 6.751, P < .001), and serum AFP level (OR = 1.001, P = .038) were associated with MVI in HCC ( P < .05). Radiographic hepatic capsular invasion and nonsmooth tumor margins identified by preoperative CT images, along with AFP levels greater than 232.2 ng/mL, are important predictors of MVI.