Expression of Peripheral Node Addressins by Plasmacytic Plaque of Children, APACHE, TRAPP, and Primary Cutaneous Angioplasmacellular Hyperplasia. Issue 6 (July 2018)

• Record Type: Journal Article
• Authors: Fernandez-Flores, Angel; Suarez Peñaranda, José M.; De Toro, Gonzalo; Alvarez Cuesta, Cesar C.; Fernández-Figueras, Maria T.; Kempf, Werner; Monteagudo, Carlos
• Is Part Of: Applied immunohistochemistry & molecular morphology. Volume 26:Issue 6(2018)
• Publication Date: 2018-07
• Subjects: pretibial lymphoplasmacytic plaque of children -- acral pseudolymphomatous angiokeratoma of children -- T-cell rich angiomatoid polypoid pseudolymphoma -- primary cutaneous angioplasmacellular hyperplasia -- MECA-79; Diagnostic immunohistochemistry -- Periodicals; Immunohistochemistry -- Periodicals; Cells -- Morphology -- Periodicals; Molecular diagnosis -- Periodicals; 616.079
• DOI: 10.1097/PAI.0000000000000433
• Languages: English
• ISSNs: 1541-2016

Abstract

Abstract : High-endothelial venules are a common feature of 3 types of cutaneous pseudolymphomas: pretibial lymphoplasmacytic plaque (PLP) of children, acral pseudolymphomatous angiokeratoma of children (APACHE), and T-cell rich angiomatoid polypoid pseudolymphoma (TRAPP). In addition, primary cutaneous angioplasmacellular hyperplasia (PCAH) overlaps with these other 3 conditions. We intend to study the expression of peripheral node addressins in PLP, APACHE, TRAPP, and PCAH. We studied 1 case of PLP, 2 cases of APACHE, 2 cases of TRAPP, and 2 cases of PCAH. Immunostainings for MECA-79 and WT-1 were obtained in all cases. All cases showed a dense lymphohistiocytic dermal inflammatory infiltrate with abundant plasma cells. In addition, HEV were prominent in all cases. Cases of PLP, APACHE, and TRAPP expressed MECA-1. Cases of PCAH did not express MECA-1. Although PLP, APACHE, and TRAPP seem to fall under the same morphologic spectrum with different clinical representations, PCAH seems to be a different entity, with histopathologic peculiarities and a different immunophenotype.