A Retrospective Study of Aimed Patch Testing With Aqueous Nickel Sulfate Hexahydrate at 30% and 15% in Patients With Dermatitis. Issue 4 (July 2018)

• Record Type: Journal Article
• Authors: Bruze, Magnus; Hindsén, Monica; Mowitz, Martin
• Is Part Of: Dermatitis. Volume 29:Issue 4(2018)
• Publication Date: 2018-07
• Subjects: Skin -- Inflammation -- Periodicals; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; Dermatitis, Contact -- Periodicals; Dermatitis, Atopic -- Periodicals; Dermatitis, Occupational -- Periodicals; Drug Eruptions -- Periodicals; 616.51
• DOI: 10.1097/DER.0000000000000388
• Languages: English
• ISSNs: 1710-3568

Abstract

Abstract : Background: Sometimes, patients with a history of metal intolerance react negatively or doubtfully to nickel at patch testing. Objective: The aim of the study was to investigate whether aqueous nickel sulfate hexahydrate at 15% and 30% traces more contact allergy than the nickel preparation in the baseline series at 5%. Methods: In the period 1995–2015, more than 800 of 16, 059 patients with a negative or doubtful patch test reaction to the petrolatum preparation of nickel at 5% on the day 3 reading were additionally tested with aqueous nickel at 15% and/or 30%. Conclusions: In this retrospective study with aimed patch testing with aqueous nickel solutions, significantly more ( P < 0.001) contact allergy was obtained as compared with the 5% preparation in petrolatum. The 30% solution was significantly better ( P < 0.001) than the 15% solution. To demonstrate that patch testing with nickel at 15% or 30% is better than the present testing with 5% requires simultaneous testing with the 3 nickel preparations.