Autoimmune hepatitis following influenza virus vaccination: Two case reports. Issue 30 (July 2018)

• Record Type: Journal Article
• Authors: Sasaki, Tokio; Suzuki, Yuji; Ishida, Kazuyuki; Kakisaka, Keisuke; Abe, Hiroaki; Sugai, Tamotsu; Takikawa, Yasuhiro
• Other Names: NA. section editor.
• Is Part Of: Medicine. Volume 97:Issue 30(2018)
• Publication Date: 2018-07
• Subjects: autoimmune hepatitis -- influenza virus vaccine; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000011621
• Languages: English
• ISSNs: 0025-7974

Abstract

Abstract: Rationale: Although immunization could possibly cause autoimmune hepatitis (AIH), to date, no cases of AIH have been reported secondary to influenza virus vaccination. This paper describes 2 women who developed AIH after receiving influenza virus vaccination. Patient concerns and diagnoses: Two women presented with elevation of liver enzymes after receiving influenza virus vaccination. Both patients were diagnosed with AIH using the International Autoimmune Hepatitis Group criteria. Intervention and outcomes: Both patients were treated with prednisolone. After the initiation of prednisolone, serum aminotransferase levels were observed to return to the reference range in both patients. Lessons: Influenza virus vaccination could trigger the development of AIH. Clinicians should be mindful of the fact that AIH can occur after influenza virus vaccination.